0001072613-20-000096.txt : 20200213 0001072613-20-000096.hdr.sgml : 20200213 20200213165022 ACCESSION NUMBER: 0001072613-20-000096 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20200213 DATE AS OF CHANGE: 20200213 GROUP MEMBERS: ARCH VENTURE PARTNERS VII, L.P. GROUP MEMBERS: ARCH VENTURE PARTNERS VII, LLC GROUP MEMBERS: CLINTON BYBEE GROUP MEMBERS: KEITH CRANDELL GROUP MEMBERS: ROBERT NELSEN SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: Syros Pharmaceuticals, Inc. CENTRAL INDEX KEY: 0001556263 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 453772460 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: 1934 Act SEC FILE NUMBER: 005-89552 FILM NUMBER: 20611553 BUSINESS ADDRESS: STREET 1: 35 CAMBRIDGE PARK DRIVE CITY: CAMBRIDGE STATE: MA ZIP: 02140 BUSINESS PHONE: 617-744-1340 MAIL ADDRESS: STREET 1: 35 CAMBRIDGE PARK DRIVE CITY: CAMBRIDGE STATE: MA ZIP: 02140 FORMER COMPANY: FORMER CONFORMED NAME: LS22, Inc. DATE OF NAME CHANGE: 20120815 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: ARCH Venture Fund VII, L.P. CENTRAL INDEX KEY: 0001402439 IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: SC 13G/A BUSINESS ADDRESS: STREET 1: 8755 W HIGGINS STREET 2: SUITE 1025 CITY: Chicago STATE: IL ZIP: 60631 BUSINESS PHONE: 773-380-6600 MAIL ADDRESS: STREET 1: 8755 W HIGGINS STREET 2: SUITE 1025 CITY: Chicago STATE: IL ZIP: 60631 FORMER COMPANY: FORMER CONFORMED NAME: Arch Venture Fund VII LP DATE OF NAME CHANGE: 20070608 SC 13G/A 1 archvii-syros_13ga318372.htm ARCH VENTURE FUND VII, L.P. - SYROS PHARMACEUTICALS, INC. -- SCHEDULE 13G/A(#3)
 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
 

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No.  3)*
 
 
 
 

Syros Pharmaceuticals, Inc.
(Name of Issuer)
 
 
 
Common Stock
(Title of Class of Securities)
 
 
 
87184Q107
(CUSIP Number)
 
 
 
December 31, 2019
(Date of Event Which Requires Filing of this Statement)
 
 
 
 
 
 
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)
☐ Rule 13d-1(c)
☒ Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.
 
The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act, but shall be subject to all other provisions of the Act (however, see the Notes).
 
 
 
CUSIP No.   87184Q107
13G
Page 2 of 12 Pages
 
1
NAMES OF REPORTING PERSONS
 
 
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
 
 
ARCH Venture Fund VII, L.P.
 
 
 
 
2
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    
(a)☐
    
(b)☐
 
 
3
SEC USE ONLY
 
 
 
 
 
 
 
4
CITIZENSHIP OR PLACE OF ORGANIZATION
 
 
Delaware
 
 
 
 
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5
SOLE VOTING POWER
 
 
0
 
 
 
 
6
SHARED VOTING POWER
 
 
3,313,817
 
 
 
 
7
SOLE DISPOSITIVE POWER
 
 
0
 
 
 
 
8
SHARED DISPOSITIVE POWER
 
 
3,313,817
 
 
 
 
9
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 
 
3,313,817
 
 
 
 
10
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
 
 
☐
 
 
 
 
11
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
 
 
7.8%
 
 
 
 
12
TYPE OF REPORTING PERSON*
 
 
PN
 
 
 
 
 
CUSIP No.   87184Q107
13G
Page 3 of 12 Pages
 
1
NAMES OF REPORTING PERSONS
 
 
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
 
 
ARCH Venture Partners VII, L.P.
 
 
 
 
2
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    
(a)☐
    
(b)☐
 
 
3
SEC USE ONLY
 
 
 
 
 
 
 
4
CITIZENSHIP OR PLACE OF ORGANIZATION
 
 
Delaware
 
 
 
 
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5
SOLE VOTING POWER
 
 
0
 
 
 
 
6
SHARED VOTING POWER
 
 
3,313,817
 
 
 
 
7
SOLE DISPOSITIVE POWER
 
 
0
 
 
 
 
8
SHARED DISPOSITIVE POWER
 
 
3,313,817
 
 
 
 
9
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 
 
3,313,817
 
 
 
 
10
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
 
 
☐
 
 
 
 
11
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
 
 
7.8%
 
 
 
 
12
TYPE OF REPORTING PERSON*
 
 
PN
 
 
 
 
 
CUSIP No.   87184Q107
13G
Page 4 of 12 Pages
 
1
NAMES OF REPORTING PERSONS
 
 
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
 
 
ARCH Venture Partners VII, LLC
 
 
 
 
2
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    
(a)☐
    
(b)☐
 
 
3
SEC USE ONLY
 
 
 
 
 
 
 
4
CITIZENSHIP OR PLACE OF ORGANIZATION
 
 
Delaware
 
 
 
 
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5
SOLE VOTING POWER
 
 
0
 
 
 
 
6
SHARED VOTING POWER
 
 
3,313,817
 
 
 
 
7
SOLE DISPOSITIVE POWER
 
 
0
 
 
 
 
8
SHARED DISPOSITIVE POWER
 
 
3,313,817
 
 
 
 
9
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 
 
3,313,817
 
 
 
 
10
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
 
 
☐
 
 
 
 
11
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
 
 
7.8%
 
 
 
 
12
TYPE OF REPORTING PERSON*
 
 
OO
 
 
 
 
 
 
CUSIP No.   87184Q107
13G
Page 5 of 12 Pages
 
1
NAMES OF REPORTING PERSONS
 
 
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
 
 
Keith Crandell
 
 
 
 
2
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    
(a)☐
    
(b)☐
 
 
3
SEC USE ONLY
 
 
 
 
 
 
 
4
CITIZENSHIP OR PLACE OF ORGANIZATION
 
 
United States of America
 
 
 
 
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5
SOLE VOTING POWER
 
 
27,953
 
 
 
 
6
SHARED VOTING POWER
 
 
3,313,817
 
 
 
 
7
SOLE DISPOSITIVE POWER
 
 
27,953
 
 
 
 
8
SHARED DISPOSITIVE POWER
 
 
3,313,817
 
 
 
 
9
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 
 
3,341,770
 
 
 
 
10
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
 
 
☐
 
 
 
 
11
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
 
 
7.9%
 
 
 
 
12
TYPE OF REPORTING PERSON*
 
 
IN
 
 
 
 
 
CUSIP No.   87184Q107
13G
Page 6 of 12 Pages
 
1
NAMES OF REPORTING PERSONS
 
 
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
 
 
Clinton Bybee
 
 
 
 
2
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    
(a)☐
    
(b)☐
 
 
3
SEC USE ONLY
 
 
 
 
 
 
 
4
CITIZENSHIP OR PLACE OF ORGANIZATION
 
 
United States of America
 
 
 
 
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5
SOLE VOTING POWER
 
 
27,952
 
 
 
 
6
SHARED VOTING POWER
 
 
3,313,817
 
 
 
 
7
SOLE DISPOSITIVE POWER
 
 
27,952
 
 
 
 
8
SHARED DISPOSITIVE POWER
 
 
3,313,817
 
 
 
 
9
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 
 
3,341,769
 
 
 
 
10
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
 
 
☐
 
 
 
 
11
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
 
 
7.9%
 
 
 
 
12
TYPE OF REPORTING PERSON*
 
 
IN
 
 
 
 
 
CUSIP No.   87184Q107
13G
Page 7 of 12 Pages
 
1
NAMES OF REPORTING PERSONS
 
 
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
 
 
Robert Nelsen
 
 
 
 
2
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
    
(a)☐
    
(b)☐
 
 
3
SEC USE ONLY
 
 
 
 
 
 
 
4
CITIZENSHIP OR PLACE OF ORGANIZATION
 
 
United States of America
 
 
 
 
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5
SOLE VOTING POWER
 
 
27,953
 
 
 
 
6
SHARED VOTING POWER
 
 
3,313,817
 
 
 
 
7
SOLE DISPOSITIVE POWER
 
 
27,953
 
 
 
 
8
SHARED DISPOSITIVE POWER
 
 
3,313,817
 
 
 
 
9
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 
 
3,341,770
 
 
 
 
10
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
 
 
☐
 
 
 
 
11
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
 
 
7.9%
 
 
 
 
12
TYPE OF REPORTING PERSON*
 
 
IN
 
 
 
 
 
 
CUSIP No.   87184Q107
13G
Page 8 of 12 Pages
 
 
 
 
Item 1(a). Name of Issuer

Syros Pharmaceuticals, Inc. (the "Issuer").
 
 
Item 1(b). Address of Issuer's Principal Executive Offices

35 CambridgePark Drive, Cambridge, MA 02140.
 

Item 2(a). Name of Person Filing
 
ARCH Venture Fund VII, L.P. (“ARCH Venture Fund VII”); ARCH Venture Partners VII, L.P. (“AVP VII LP”); ARCH Venture Partners VII, LLC (“AVP VII LLC”) (collectively, the “Reporting Entities” and individually, each a “Reporting Entity”); and Keith Crandell (“Crandell”), Robert Nelsen (“Nelsen”) and Clinton Bybee (“Bybee”) (collectively, the “Managing Directors” and individually, each a “Managing Director”).  The Reporting Entities and the Managing Directors collectively are referred to as the “Reporting Persons”.
 

Item 2(b). Address of Principal Business Office or, if none, Residence

8755 W. Higgins Avenue, Suite 1025, Chicago, IL 60631
 

Item 2(c). Citizenship

ARCH Venture Fund VII and AVP VII LP are limited partnerships organized under the laws of the State of Delaware. AVP VII LLC is a limited liability company organized under the laws of the State of Delaware.  Each Managing Director is a US citizen.
 

Item 2(d). Title of Class of Securities

Common stock, par value $0.001 per share.
 
 
Item 2(e). CUSIP Number

87184Q107
 

Item 3.
If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), Check Whether the Person Filing is a:
 
Not Applicable.
 
 
Item 4. Ownership
 
 
(a)
Amount beneficially owned:
 
ARCH Venture Fund VII is the record owner of 3,313,817 shares of Common Stock (the “Record Shares”) as of December 31, 2019.  AVP VII LP, as the sole general partner of ARCH Venture Fund VII, may be deemed to beneficially own the Record Shares.  AVP VII LLC, as the sole general partner of AVP VII LP, may be deemed to beneficially own the Record Shares.  As managing directors of AVP VII LLC, each Managing Director may also be deemed to share the power to direct the disposition and vote of the Record Shares. In addition, as of December 31, 2019, Crandell is a holder of 27,953 Shares of Common Stock, Bybee is a holder of 27,952 shares of Common Stock, and Nelsen is the holder of 27,953 shares of Common Stock.
 
 
(b)
Percent of class:
 
See line 11 of the cover sheets.  The percentages set forth on the cover sheet for each Reporting Person is based upon 42,441,227 shares of common stock outstanding as of October 31, 2019 as reported on the Issuer’s Form 10-Q as filed with the Securities and Exchange Commission on November 12, 2019.
 
CUSIP No.   87184Q107
13G
Page 9 of 12 Pages
 
 
 
 
 
(c)
Number of shares as to which such person has:
 
(i)    Sole power to vote or to direct the vote:
 
See line 5 of the cover sheets.
 
(ii)   Shared power to vote or to direct the vote:
 
See line 6 of the cover sheets.
 
(iii)  Sole power to dispose or to direct the disposition:
 
    See line 7 of the cover sheets.
 
(iv)  Shared power to dispose or to direct the disposition:
 
    See line 8 of the cover sheets.
 
Each Reporting Person disclaims beneficial ownership of such shares of Common Stock except for the shares, if any, such Reporting Person holds of record.
 
 
Item 5. Ownership of Five Percent or Less of a Class

Not Applicable.
 

Item 6. Ownership of More Than Five Percent on Behalf of Another Person

Not Applicable.

 
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company

Not Applicable.
 

Item 8. Identification and Classification of Members of the Group

Not Applicable.
 

Item 9. Notice of Dissolution of Group

Not Applicable.
 
 
Item 10.
Certification
 
Not Applicable.

CUSIP No.   87184Q107
13G
Page 10 of 12 Pages
 
 
SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated:       February 13, 2020
 
 
 
ARCH VENTURE FUND VII, L.P.
 
 
By:   ARCH Venture Partners VII, L.P.
           its General Partner
 
 
 By:   ARCH Venture Partners VII, LLC
 
                  its General Partner
 
 
  By:                   *                                         
            
                          Keith Crandell
 
                          Managing Director
 
 
 
ARCH VENTURE PARTNERS VII, L.P.
 
 
By:   ARCH Venture Partners VII, LLC
           its General Partner
 
 
 By:                    *                                         
 
                  Keith Crandell
                    Managing Director
 
 
 
ARCH VENTURE PARTNERS VII, LLC
 
 
By:                       *                                         
           Keith Crandell
           Managing Director
 
 
 
                             *                                         
  Keith Crandell
 
 
                             *                                         
 
Robert Nelsen
 
 
                             *                                         
 
Clinton Bybee
 
 
 
     
* By:  /s/ Mark McDonnell                            
   
           Mark McDonnell as
   
          Attorney-in-Fact
    
 
This Amendment No. 3 to Schedule 13G was executed by Mark McDonnell pursuant to Powers of Attorney attached hereto as Exhibit 2 and incorporated herein by reference.
CUSIP No.   87184Q107
13G
Page 11 of 12 Pages
 
Exhibit 1

AGREEMENT

Pursuant to Rule 13d-1-(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of shares of stock of Syros Therapeutics, Inc.

This Agreement may be executed in any number of counterparts, each of which shall be deemed an original.
 
 
Dated:   February 13, 2020
ARCH VENTURE FUND VII, L.P.
 
 
By:   ARCH Venture Partners VII, L.P.
           its General Partner
 
 
 By:   ARCH Venture Partners VII, LLC
 
                  its General Partner
 
 
  By:                   *                                         
            
                          Keith Crandell
 
                          Managing Director
 
 
 
ARCH VENTURE PARTNERS VII, L.P.
 
 
By:   ARCH Venture Partners VII, LLC
           its General Partner
 
 
 By:                    *                                         
 
                  Keith Crandell
                    Managing Director
 
 
 
ARCH VENTURE PARTNERS VII, LLC
 
 
By:                       *                                         
           Keith Crandell
           Managing Director
 
 
 
                             *                                         
  Keith Crandell
 
 
                             *                                         
 
Robert Nelsen
 
 
                             *                                         
 
Clinton Bybee
 
 
 
     
* By:  /s/ Mark McDonnell                            
   
           Mark McDonnell as
   
          Attorney-in-Fact
    
 
This Agreement was executed by Mark McDonnell pursuant to Powers of Attorney attached hereto as Exhibit 2 and incorporated herein by reference.
 
CUSIP No.   87184Q107
13G
Page 12 of 12 Pages
 
Exhibit 2

POWERS OF ATTORNEY
 
KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Mark McDonnell his true and lawful attorney-in-fact, with full power of substitution, to sign any and all instruments, certificates and documents that may be necessary, desirable or appropriate to be executed on behalf of himself as an individual or in his capacity as a direct or indirect general partner, director, officer or manager of any partnership, corporation or limited liability company, pursuant to section 13 or 16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and any and all regulations promulgated thereunder, and to file the same, with all exhibits thereto, and any other documents in connection therewith, with the Securities and Exchange Commission, and with any other entity when and if such is mandated by the Exchange Act or by the Financial Industry Regulatory Authority, granting unto said attorney-in-fact full power and authority to do and perform each and every act and thing necessary, desirable or appropriate, fully to all intents and purposes as he might or could do in person, thereby ratifying and confirming all that said attorney-in-fact, or his substitutes, may lawfully do or cause to be done by virtue hereof.
 
IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 7th day of May, 2013.
 
 
 
ARCH VENTURE FUND VII, L.P.
 
 
By:   ARCH Venture Partners VII, L.P.
           its General Partner
 
 
 By:   ARCH Venture Partners VII, LLC
 
                  its General Partner
 
 
  By:  /s/ Keith Crandell                                
 
                          Managing Director
 
 
 
ARCH VENTURE PARTNERS VII, L.P.
 
 
By:   ARCH Venture Partners VII, LLC
           its General Partner
 
 
 By:   /s/ Keith Crandell                                
                    Managing Director
 
 
 
ARCH VENTURE PARTNERS VII, LLC
 
 
By:   /s/ Keith Crandell                                
           Managing Director
 
 
 
/s/ Keith Crandell                                        
  Keith Crandell
 
 
/s/ Robert Nelsen                                        
 
Robert Nelsen
 
 
/s/ Clinton Bybee                                        
 
Clinton Bybee